Antibody-Drug Conjugates (ADCs) Manufacturing

ADCs are an advanced cancer therapy designed to precisely target and deliver cytotoxic agents directly to cancer cells.

ILC Dover is the global leader in high-containment systems for handling potent pharmaceutical ingredients. Since 1997, we’ve pioneered single-use isolator technology that lowers capital and operating costs while delivering proven containment performance. Designed for highly potent APIs, including the most powerful toxin linkers, our systems consistently achieve below 1.0 nanogram / m3 airborne concentration containment limit, verified through ISPE SMEPAC testing and SafeBridge Consultants analysis. With no cleaning or filter changes required, the fully disposable design allows safe disposal and faster changeover, getting production running again in hours, not days.

ILC Dover has developed technology for containment across the ADC workflow. The innovative designs protect operators and the environment, leveraging single-use systems that reduce risks of contamination and costs associated with cleaning stainless steel components. This improves production efficiency to when cleaning is eliminated, and the equipment is available quickly.

Let ILC Dover be your trusted partner in ADC Manufacturing —where quality, flexibility, and innovation come together.

The customer problem is payload handling and containment. That needs to be stated first and then technology can be discussed.

Across the workflow for manufacturing antibody drug conjugates, there are many challenges that require unique solutions. From solubilizing the toxin linker to chromatography and lyophilization, ILC Dover provides cost effective single use technology. We have proven solutions that do more than provide containment to protect operators and the environment:

• Streamline production by eliminating cleaning and boosts efficiency and capacity
• Single use technology like flexible film isolators have easy-to-add options to overcome site specific challenges. Improvements and changes are easily adapted after the installation with no lost production time
• Containment systems that protect operators, facilities, and the product from contamination to the nanogram level. Test results are validated by 3rd party hygienists.