Meeting Demand for GLP-1 Therapies

ILC Dover provides end-to-end containment solutions supporting every stage of GLP-1 manufacturing, from solid-phase peptide synthesis (SPPS) through downstream solids handling and formulation. As demand for GLP-1 therapies grows across multiple indications, manufacturers face increasingly complex peptide processes and require scalable, contamination-free systems that protect both product integrity and operator safety.

Our portfolio is engineered to meet the specific requirements of GLP-1 peptide synthesis, including SPPS-based semaglutide and tirzepatide manufacturing. From contained solids charging to Flexible Isolation, ILC Dover delivers an integrated suite of purpose-built solutions supporting both injectable and oral solid dose workflows. With standardized, cost-effective designs as well as fully customized systems, ILC Dover enables safe, efficient, and compliant GLP-1 drug substance production, backed by a global service network supporting manufacturers worldwide.

Contained solids charging is a critical first step in GLP-1 production, particularly in SPPS processes involving harsh solvents and reactive environments. The  DoverPac® system provides reliable containment for both bulk and small-volume solid additions, with adaptable hardware connections compatible with a wide range of reactor nozzle sizes. To further enhance operator safety and ergonomics, the JetMixer powder delivery system enables floor-level solids addition while efficiently transferring material from DoverPac® containers, Big Bag Stations, or Drum/Bag Dump Stations into an inline mixing system, all within a fully contained, explosion-proof design.

Let ILC Dover be your trusted partner in GLP-1 Manufacturing - where quality, flexibility, and innovation come together.

GLP1 manufacturers face several challenges, including the need for robust containment of potent peptide intermediates, safe and efficient solids charging, managing harsh solvent environments typical of semaglutide and tirzepatide manufacturing processes, reducing cleaning and contamination risks, and improving operator ergonomics. ILC Dover addresses these challenges through an integrated portfolio of GLP1 containment solutions such as DoverPac system for closed solids charging, ArmorFlex isolators for contamination control, and JetMixer technology that supports safe, floor level powder handling. With corrosion resistant materials, CIP ready hardware, and both standardized and customized designs, ILC Dover helps improve process safety, efficiency, flexibility, and overall reliability across the GLP1 drug substance production workflow.