GLP‑1 Oral Solid Dose Containment Solutions

End‑to‑End Containment for GLP‑1 Oral Solid Dose Workflows

GLP‑1 therapies have traditionally been delivered as injectable formulations using pen devices. Today, oral solid dosage (OSD) forms are becoming increasingly available and, in many cases, preferred by patients. Tablets and capsules introduce new manufacturing opportunities, along with new containment and material handling challenges.

ILC Dover provides flexible containment and material transfer solutions designed to support the entire GLP‑1 oral solid dose workflow, from powder handling through final dosage form processing.

Containment Challenges in GLP‑1 OSD Manufacturing

Handling GLP‑1 compounds in solid or powder form significantly increases the risk of operator exposure, while also introducing potential cleaning and cross‑contamination concerns. Effective containment must be applied not only at individual unit operations, but also across all material transfers throughout the OSD process.

A well‑designed containment and transfer strategy is essential to protect operators, preserve product integrity, and maintain efficient, compliant manufacturing.

Flexible Isolation Across the OSD Workflow

ILC Dover flexible isolators are easily adapted to the full range of OSD unit operations, providing true isolation and containment at the source. Unlike hard‑wall isolators, which can be difficult to adapt, or downflow booths, which often provide incomplete containment, flexible isolators offer the versatility required for complex OSD workflows.

GLP-1’s dosage includes tablet and capsule forms that use dry granulation systems as well as spray drying. ILC Dover’s vast library of proven solutions across these workflows are applied using standard configurations and site specific customized solutions.

Chemical Synthesis Workflow

Spray Drying and Tableting Workflow

Contained Powder Transfer Solutions

Powder transfers throughout the OSD process require a range of secure connection options to ensure fully contained handling. ILC Dover’s family of powder bags, including EZ BioPac and EZ PowderZip, enable secure connections to tri‑clamp ports and compatibility with split butterfly valves.

For larger discharge ports, Continuous Liner technology captures material at the source and integrates seamlessly with flexible isolator systems, enabling contained charging into subsequent process steps.

Maximizing Yield and Protecting High‑Value GLP‑1 Compounds

GLP‑1 powders are typically lightweight, dusty, and highly valuable. Ensuring complete discharge with minimal retention or material loss is critical to cGMP compliance and batch‑to‑batch consistency.

ILC Dover solutions are manufactured using ArmorFlex film, a proprietary, static‑dissipative material engineered to release up to 99.4% of powder during charging. Combined with 3D construction that eliminates hold‑up areas, this design minimizes product loss, reduces cleaning burden, and helps prevent batch shrinkage.

Learn more about our end-to-end GLP-1 manufacturing containment approach in our main GLP-1 Therapeutic Workflow page.

ArmorFlex® Films

The premier film for pharmaceutical and biopharmaceutical powder handling.

DoverPac®

DoverPac® Containment Systems are the global premier products for disposable process and powder containment systems.

Continuous Liners

Effective and easy-to-use system for containing APIs and other hazardous compounds.

soloPURE™ Flexible Aseptic Isolator

The future of sterile manufacturing is soloPURE™.

ILC Dover’s soloPURE™ flexible aseptic isolator is a cost-effective, closed-barrier system for sterile manufacturing that provides a closed, Grade-A, aseptic environment for fill finish activities requiring positive and negative pressure.

See for youself how our solutions for Pharmaceutical and Biopharmaceutical Manufacturing can improve your process

ILC Product Photo Employee Group No Background v2

GLP-1 Oral Solid Dose Solutions